The NPC meme essentially meant to ridicule the post-election perpetual outrage culture in which liberals simply parrot the latest talking points from their favorite pundits, who do their thinking for them.
The 4chan version is a simple greyed out, expressionless face known as "NPC Wojak" (https://knowyourmeme.com/memes/npc-wojak) - which has triggered the left so hard that Twitter conducted a mass-banning campaign for accounts promoting the meme, and the New York Times wrote an entire article trying to figure it out.
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https://www.zerohedge.com/news/2018-10-16/4chan-sparks-mass-triggering-npc-meme-twitter-responds-ban-hammer